abstract：:Stephan Achenbach reviews the history of coronary computer tomography angiography and discusses its further evolution. ...

journal_title：European heart journal

authors： Achenbach S

更新日期：2016-02-21 00:00:00

abstract：AIMS:Midwall myocardial fibrosis on cardiovascular magnetic resonance (CMR) is a marker of early ventricular decompensation and adverse outcomes in aortic stenosis (AS). We aimed to develop and validate a novel clinical score using variables associated with midwall fibrosis. METHODS AND RESULTS:One hundred forty-seven...

journal_title：European heart journal

authors： Chin CW,Messika-Zeitoun D,Shah AS,Lefevre G,Bailleul S,Yeung EN,Koo M,Mirsadraee S,Mathieu T,Semple SI,Mills NL,Vahanian A,Newby DE,Dweck MR

更新日期：2016-02-21 00:00:00

abstract：AIMS:Recent randomized trials suggest that intensive glycaemic control fails to reduce heart failure-related events in patients with diabetes. The molecular cues underlying persistent myocardial damage despite normoglycaemia restoration remain elusive. MicroRNAs (miRNAs), a class of small non-coding RNAs, orchestrate t...

journal_title：European heart journal

authors： Costantino S,Paneni F,Lüscher TF,Cosentino F

更新日期：2016-02-07 00:00:00

abstract：AIMS:In the dual antiplatelet therapy (DAPT) study, continued thienopyridine beyond 12 months after drug-eluting stent placement was associated with increased mortality compared with placebo. We sought to evaluate factors related to mortality in randomized patients receiving either drug-eluting or bare metal stents in ...

journal_title：European heart journal

authors： Mauri L,Elmariah S,Yeh RW,Cutlip DE,Steg PG,Windecker S,Wiviott SD,Cohen DJ,Massaro JM,D'Agostino RB Sr,Braunwald E,Kereiakes DJ,DAPT Study Investigators.

更新日期：2016-01-21 00:00:00

abstract：AIMS:Cardiomyopathies are a heterogeneous group of disorders associated with premature death due to ventricular arrhythmia or heart failure. The purpose of this study was to examine the characteristics of patients enrolled in the pilot phase of the EURObservational Research Programme (EORP) cardiomyopathy registry. ME...

journal_title：European heart journal

authors： Elliott P,Charron P,Blanes JR,Tavazzi L,Tendera M,Konté M,Laroche C,Maggioni AP,EORP Cardiomyopathy Registry Pilot Investigators.

更新日期：2016-01-07 00:00:00

abstract：AIMS:Growth differentiation factor 11 and/or its homologue growth differentiation factor 8 (GDF11/8) reverses age-related cardiac hypertrophy and vascular ageing in mice. We investigated whether GDF11/8 associates with cardiovascular outcomes, left ventricular hypertrophy (LVH), or age in humans. METHODS AND RESULTS:W...

journal_title：European heart journal

authors： Olson KA,Beatty AL,Heidecker B,Regan MC,Brody EN,Foreman T,Kato S,Mehler RE,Singer BS,Hveem K,Dalen H,Sterling DG,Lawn RM,Schiller NB,Williams SA,Whooley MA,Ganz P

更新日期：2015-12-21 00:00:00

abstract：:Modern-day stenting procedures leverage advances in pharmacotherapy and device innovation. Patients treated with contemporary antiplatelet agents, peri-procedural antithrombin therapy and new-generation drug-eluting stents (DES) have excellent outcomes over the short to medium term. Indeed, coupled with the reducing c...

journal_title：European heart journal

authors： Byrne RA,Joner M,Kastrati A

更新日期：2015-12-14 00:00:00

abstract：AIMS:High-density lipoproteins (HDLs) are considered as anti-atherogenic. Recent experimental findings suggest that their biological properties can be modified in certain clinical conditions by accumulation of serum amyloid A (SAA). The effect of SAA on the association between HDL-cholesterol (HDL-C) and cardiovascular...

journal_title：European heart journal

authors： Zewinger S,Drechsler C,Kleber ME,Dressel A,Riffel J,Triem S,Lehmann M,Kopecky C,Säemann MD,Lepper PM,Silbernagel G,Scharnagl H,Ritsch A,Thorand B,de las Heras Gala T,Wagenpfeil S,Koenig W,Peters A,Laufs U,Wanner C,

更新日期：2015-11-14 00:00:00

abstract：AIMS:The choice of resynchronization therapy between with (CRT-D) and without (CRT-P) a defibrillator remains a contentious issue. Cause-of-death analysis among CRT-P, compared with CRT-D, patients could help evaluate the extent to which CRT-P patients would have additionally benefited from a defibrillator in a daily c...

journal_title：European heart journal

authors： Marijon E,Leclercq C,Narayanan K,Boveda S,Klug D,Lacaze-Gadonneix J,Defaye P,Jacob S,Piot O,Deharo JC,Perier MC,Mulak G,Hermida JS,Milliez P,Gras D,Cesari O,Hidden-Lucet F,Anselme F,Chevalier P,Maury P,Sadoul N,

更新日期：2015-11-01 00:00:00

abstract：AIMS:The management and outcomes of patients with functional moderate/severe mitral regurgitation and severe left ventricular (LV) systolic dysfunction are not well defined. We sought to determine the characteristics, management strategies, and outcomes of patients with moderate or severe mitral regurgitation (MR) and ...

journal_title：European heart journal

authors： Samad Z,Shaw LK,Phelan M,Ersboll M,Risum N,Al-Khalidi HR,Glower DD,Milano CA,Alexander JH,O'Connor CM,Wang A,Velazquez EJ

更新日期：2015-10-21 00:00:00

abstract：:The evaluation for European Union market approval of coronary stents falls under the Medical Device Directive that was adopted in 1993. Specific requirements for the assessment of coronary stents are laid out in supplementary advisory documents. In response to a call by the European Commission to make recommendations ...

journal_title：European heart journal

authors： Byrne RA,Serruys PW,Baumbach A,Escaned J,Fajadet J,James S,Joner M,Oktay S,Jüni P,Kastrati A,Sianos G,Stefanini GG,Wijns W,Windecker S

更新日期：2015-10-07 00:00:00

abstract：AIMS:To evaluate the effectiveness of Dietary Approaches to Stop Hypertension (DASH) by one-off dietary counselling on reducing cardiovascular risk factors among Chinese Grade 1 hypertensive patients in primary care. METHODS AND RESULTS:A parallel-group, randomized controlled trial (ChiCTR-TRC-13003014) was conducted ...

journal_title：European heart journal

authors： Wong MC,Wang HH,Kwan MW,Fong BC,Chan WM,Zhang DX,Li ST,Yan BP,Coats AJ,Griffiths SM

更新日期：2015-10-07 00:00:00

abstract：AIMS:Oral glucose-lowering medications are associated with excess risk of heart failure (HF). Given the absence of comparative data among drug classes, we performed a retrospective study in 32 Health Services of 16 Italian regions accounting for a population of 18 million individuals, to assess the association between ...

journal_title：European heart journal

authors： Fadini GP,Avogaro A,Degli Esposti L,Russo P,Saragoni S,Buda S,Rosano G,Pecorelli S,Pani L,OsMed Health-DB Network.

更新日期：2015-09-21 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is characterized by multiple pathophysiologic abnormalities. With time, multiple glucose-lowering medications are commonly required to reduce and maintain plasma glucose concentrations within the normal range. Type 2 diabetes mellitus individuals also are at a very high risk for microva...

journal_title：European heart journal

authors： Ferrannini E,DeFronzo RA

更新日期：2015-09-07 00:00:00

abstract：AIMS:Intense exercise places disproportionate strain on the right ventricle (RV) which may promote pro-arrhythmic remodelling in some athletes. RV exercise imaging may enable early identification of athletes at risk of arrhythmias. METHODS AND RESULTS:Exercise imaging was performed in 17 athletes with RV ventricular a...

journal_title：European heart journal

authors： La Gerche A,Claessen G,Dymarkowski S,Voigt JU,De Buck F,Vanhees L,Droogne W,Van Cleemput J,Claus P,Heidbuchel H

更新日期：2015-08-07 00:00:00

abstract：:A look back on the history of the European Society of Cardiology which officially came into existence in 1950. ...

journal_title：European heart journal

authors：

更新日期：2015-07-21 00:00:00

abstract：AIMS:It has been proposed that competitive sport increases the risk of ventricular tachyarrhythmias (VTA) and death in patients with arrhythmogenic right-ventricular cardiomyopathy (ARVC). However, it is unknown whether this only applies to competitive sport or if recreational sports activity also increases the risk of...

journal_title：European heart journal

authors： Ruwald AC,Marcus F,Estes NA 3rd,Link M,McNitt S,Polonsky B,Calkins H,Towbin JA,Moss AJ,Zareba W

更新日期：2015-07-14 00:00:00

abstract：:Contraceptive counselling should begin early in females with heart disease, preferably directly after the start of menstruation. In coming to a decision about the method of contraception, the following issues should be considered: (i) the risk of pregnancy for the mother and the consequences of an unplanned pregnancy;...

journal_title：European heart journal

authors： Roos-Hesselink JW,Cornette J,Sliwa K,Pieper PG,Veldtman GR,Johnson MR

更新日期：2015-07-14 00:00:00

abstract：AIMS:The effect of statins on risk of heart failure (HF) hospitalization and HF death remains uncertain. We aimed to establish whether statins reduce major HF events. METHODS AND RESULTS:We searched Medline, EMBASE, and the Cochrane Central Register of Controlled Trials for randomized controlled endpoint statin trials...

journal_title：European heart journal

authors： Preiss D,Campbell RT,Murray HM,Ford I,Packard CJ,Sattar N,Rahimi K,Colhoun HM,Waters DD,LaRosa JC,Amarenco P,Pedersen TR,Tikkanen MJ,Koren MJ,Poulter NR,Sever PS,Ridker PM,MacFadyen JG,Solomon SD,Davis BR,Simpson

更新日期：2015-06-21 00:00:00

abstract：:The benefits of exercise are irrefutable. Individuals engaging in regular exercise have a favourable cardiovascular risk profile for coronary artery disease and reduce their risk of myocardial infarction by 50%. Exercise promotes longevity of life, reduces the risk of some malignancies, retards the onset of dementia, ...

journal_title：European heart journal

authors： Sharma S,Merghani A,Mont L

更新日期：2015-06-14 00:00:00

abstract：:Priorities for unanswered questions concerning major areas of cardiovascular disease are being sought by the British Cardiovascular Society, using the methods of the James Lind Alliance, which involves clinicians and patients in an equal partnership, reports Barry Shurlock PhD. ...

journal_title：European heart journal

authors：

更新日期：2015-06-01 00:00:00

abstract：:Nitric oxide inhalation in myocardial infarction patients sends mixed messages, but may offer some benefit. ...

journal_title：European heart journal

authors： Tofield A

更新日期：2015-05-14 00:00:00

abstract：AIMS:Three methods are used to identify dysglycaemia: fasting plasma glucose (FPG), 2-h post-load plasma glucose (2hPG) from the oral glucose tolerance test (OGTT), and glycated haemoglobin A1c (HbA1c). The aim was to describe the yield and concordance of FPG, HbA1c, and 2hPG alone, or in combination, to identify dysgl...

journal_title：European heart journal

authors： Gyberg V,De Bacquer D,Kotseva K,De Backer G,Schnell O,Sundvall J,Tuomilehto J,Wood D,Rydén L,EUROASPIRE IV Investigators.

更新日期：2015-05-14 00:00:00

abstract：AIMS:Prognostic importance of coronary vessel dominance in patients with ST-elevation myocardial infarction (STEMI) remains uncertain. The aim of this study was to assess influence of coronary vessel dominance on the short- and long-term outcome after STEMI. METHODS AND RESULTS:Coronary angiographic images of consecut...

journal_title：European heart journal

authors： Veltman CE,van der Hoeven BL,Hoogslag GE,Boden H,Kharbanda RK,de Graaf MA,Delgado V,van Zwet EW,Schalij MJ,Bax JJ,Scholte AJ

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:While prior work has suggested that a high-grade atrioventricular block (HAVB) in the setting of an acute coronary syndrome (ACS) is associated with in-hospital death, limited information is available on the incidence of, and death associated with, HAVB in ACS patients receiving contemporary management. MET...

journal_title：European heart journal

authors： Singh SM,FitzGerald G,Yan AT,Brieger D,Fox KA,López-Sendón J,Yan RT,Eagle KA,Steg PG,Budaj A,Goodman SG

更新日期：2015-04-21 00:00:00

abstract：AIM:Cardiosphere-derived cells (CDCs) produce regenerative effects in the post-infarct setting. However, it is unclear whether CDCs are beneficial in non-ischaemic dilated cardiomyopathy (DCM). We tested the effects of CDC transplantation in mice with cardiac-specific Gαq overexpression, which predictably develop progr...

journal_title：European heart journal

authors： Aminzadeh MA,Tseliou E,Sun B,Cheng K,Malliaras K,Makkar RR,Marbán E

更新日期：2015-03-21 00:00:00

abstract：AIMS:Supernatants of serum-free cultured mononuclear cells (MNC) contain a mix of immunomodulating factors (secretome), which have been shown to attenuate detrimental inflammatory responses following myocardial ischaemia. Inflammatory dilated cardiomyopathy (iDCM) is a common cause of heart failure in young patients. E...

journal_title：European heart journal

authors： Hoetzenecker K,Zimmermann M,Hoetzenecker W,Schweiger T,Kollmann D,Mildner M,Hegedus B,Mitterbauer A,Hacker S,Birner P,Gabriel C,Gyöngyösi M,Blyszczuk P,Eriksson U,Ankersmit HJ

更新日期：2015-03-14 00:00:00

abstract：AIM:Heart disease is recognized as a consequence of dysregulation of cardiac gene regulatory networks. Previously, unappreciated components of such networks are the long non-coding RNAs (lncRNAs). Their roles in the heart remain to be elucidated. Thus, this study aimed to systematically characterize the cardiac long no...

journal_title：European heart journal

authors： Ounzain S,Micheletti R,Beckmann T,Schroen B,Alexanian M,Pezzuto I,Crippa S,Nemir M,Sarre A,Johnson R,Dauvillier J,Burdet F,Ibberson M,Guigó R,Xenarios I,Heymans S,Pedrazzini T

更新日期：2015-02-07 00:00:00

abstract：BACKGROUND:The EURObservational Research Programme-Atrial Fibrillation General Registry Pilot Phase (EORP-AF Pilot) provides systematic collection of contemporary data regarding the management and treatment of 3119 subjects with AF from 9 member European Society of Cardiology (ESC) countries. In this analysis, we repor...

journal_title：European heart journal

authors： Lip GY,Laroche C,Ioachim PM,Rasmussen LH,Vitali-Serdoz L,Petrescu L,Darabantiu D,Crijns HJ,Kirchhof P,Vardas P,Tavazzi L,Maggioni AP,Boriani G

更新日期：2014-12-14 00:00:00

abstract：AIMS:Patients undergoing catheter ablation for atrial fibrillation (AF) often experience recurrent arrhythmias within the first few months post-ablation. We aimed to investigate whether short-term use of amiodarone to prevent early arrhythmias following radiofrequency ablation for AF could reduce later recurrence. MET...

journal_title：European heart journal

authors： Darkner S,Chen X,Hansen J,Pehrson S,Johannessen A,Nielsen JB,Svendsen JH

更新日期：2014-12-14 00:00:00

abstract：AIM:Cross-sectional studies reported associations between short leucocyte telomere length (LTL) and measures of vascular and cardiac damage. However, the contribution of LTL dynamics to the age-related process of cardiovascular (CV) remodelling remains unknown. In this study, we explored whether the rate of LTL shorten...

journal_title：European heart journal

authors： Masi S,D'Aiuto F,Martin-Ruiz C,Kahn T,Wong A,Ghosh AK,Whincup P,Kuh D,Hughes A,von Zglinicki T,Hardy R,Deanfield JE,NSHD scientific and data collection teams.

更新日期：2014-12-07 00:00:00

abstract：AIMS:Dysregulation of the bone morphogenetic protein receptor type 2 (BMPR2) is a hallmark feature that has been described in several forms of pulmonary hypertension. We recently identified the microRNA miR-20a within a highly conserved pathway as a regulator of the expression of BMPR2. To address the pathophysiologica...

journal_title：European heart journal

authors： Brock M,Samillan VJ,Trenkmann M,Schwarzwald C,Ulrich S,Gay RE,Gassmann M,Ostergaard L,Gay S,Speich R,Huber LC

更新日期：2014-12-01 00:00:00

abstract：:The first marathon run as an athletic event took place in the context of the Olympic Games in 1896 in Athens, Greece. Today, participation in a 'marathon run' has become a global phenomenon attracting young professional athletes as well as millions of mainly middle-aged amateur athletes worldwide each year. One of the...

journal_title：European heart journal

authors： Predel HG

更新日期：2014-11-21 00:00:00

abstract：AIMS:Whereas endogenous carbon monoxide (CO) is cytoprotective at physiologic levels, excess CO concentrations are associated with cardiometabolic risk and may represent an important marker of progression from subclinical to clinical cardiovascular disease (CVD). METHODS AND RESULTS:In 1926 participants of the Framing...

journal_title：European heart journal

authors： Cheng S,Enserro D,Xanthakis V,Sullivan LM,Murabito JM,Benjamin EJ,Polak JF,O'Donnell CJ,Wolf PA,O'Connor GT,Keaney JF,Vasan RS

更新日期：2014-11-07 00:00:00

abstract：:A new European Heart Journal, Cardiovascular Pharmacotherapy, was launched at the ESC Congress 2014 in Barcelona and begins publication in February 2014. ...

journal_title：European heart journal

authors： Ozcan J

更新日期：2014-09-07 00:00:00

abstract：AIM:A genetic variant (rs20417) of the PTGS2 gene, encoding for COX-2, has been associated with decreased COX-2 activity and a decreased risk of cardiovascular disease (CVD). However, this genetic association and the role of COX-2 in CVD remain controversial. METHODS AND RESULTS:The association of rs20417 with CVD was...

journal_title：European heart journal

authors： Ross S,Eikelboom J,Anand SS,Eriksson N,Gerstein HC,Mehta S,Connolly SJ,Rose L,Ridker PM,Wallentin L,Chasman DI,Yusuf S,Paré G

更新日期：2014-09-01 00:00:00

abstract：AIMS:Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening condition characterized by markedly elevated circulating levels of low-density lipoprotein cholesterol (LDL-C) and accelerated, premature atherosclerotic cardiovascular disease (ACVD). Given recent insights into the heterogeneity of geneti...

journal_title：European heart journal

authors： Cuchel M,Bruckert E,Ginsberg HN,Raal FJ,Santos RD,Hegele RA,Kuivenhoven JA,Nordestgaard BG,Descamps OS,Steinhagen-Thiessen E,Tybjærg-Hansen A,Watts GF,Averna M,Boileau C,Borén J,Catapano AL,Defesche JC,Hovingh GK,Hump

更新日期：2014-08-21 00:00:00

abstract：BACKGROUND:Myocardial ischaemia occurs principally in the subendocardial layer, whereas conventional myocardial perfusion imaging provides no information on the transmural myocardial blood flow (MBF) distribution. Subendocardial perfusion measurements and quantification of the transmural perfusion gradient (TPG) could ...

journal_title：European heart journal

authors： Danad I,Raijmakers PG,Harms HJ,Heymans MW,van Royen N,Lubberink M,Boellaard R,van Rossum AC,Lammertsma AA,Knaapen P

更新日期：2014-08-14 00:00:00

abstract：:The author reviews statistical methods commonly applied in economic evaluations that rely on individual patient-level data. The paper includes a review of foundational concepts, unique characteristics of health economic data, and methods developed to address them. The paper then highlights issues that should be consid...

journal_title：European heart journal

authors： Reed SD

更新日期：2014-07-01 00:00:00

abstract：:Although the number of individuals reaching 80 who are considered to be healthy is increasing, the very elderly are likely to have long-term conditions, to report symptoms and/or be taking at least one regular medication. The impact of antihypertensive treatment has to be taken into account in this context. The treatm...

journal_title：European heart journal

authors： Peters R,Beckett N,McCormack T,Fagard R,Fletcher A,Bulpitt C

更新日期：2014-07-01 00:00:00